Publications

Chemistry Research Group

2025

  • Kwok, O. C. H.; Liu, Y.; Patel, S.; Paulus, W.; Winnik, M. A. Coalescence And Film Formation Of A Low Molecular Weight Polyurethane Dispersions Designed For Radiation Cure. Progress in Organic Coatings 2025, 208 (2025). DOI
  • Georgiou, C. J.; Brown, M. K.; Cai, Z.; Alshafai, L.; Gao, A.; Rutka, J. T.; Winnik, M. A.; Reilly, R. M. Convection-Enhanced Delivery Of [177Lu]Lu-Labeled Gold Nanoparticles Combined With Anti-Pd1 Checkpoint Immunotherapy Improves The Survival Of Immunocompetent C57Bl/6J Mice With Orthotopic Gl261 Murine Glioma Tumors. Nuclear Medicine and Biology 2025, 140–141. DOI
  • Song, S.; Xu, J. - T.; Zhou, H.; Manners, I.; Winnik, M. A. Focal Point Association Of Core-Crystalline Micelles With An Amphiphilic Corona Block. Journal of the American Chemical Society 2025, 147 (11), 9919–9930. DOI
  • Abtahi, M.; Wong, E. C. N.; Liu, Y.; Winnik, M. A. Investigating The Competitive Adsorption Of Polymer-Bisphosphonate Ligands On Lanthanide Nanoparticles. Langmuir 2025. DOI
  • Wang, Y.; Kim, K. Taek; Manners, I.; Winnik, M. A. Organometallic‐Polypeptide Block Copolymers: Synthesis And Crystallization‐Driven Self‐Assembly In Aqueous Solutions To Rod‐Like And Plate‐Like Micelles With Polypeptide Coronas. Chemistry–A European Journal 2025, 31 (16). DOI
  • Wong, E. C. N.; Yang, T.; Zhang, Y.; Liu, Y.; Majonis, D.; Abtahi, M.; Chen, X.; Li, X.; Hawrysh, P.; Closson, T.; Paluan, S.; Winnik, M. A. A Platinum Polymer Probe For Multiplexed Single Cell Suspension Mass Cytometry And Imaging Mass Cytometry Assays. Chemical Engineering Journal 2025, 505. DOI
  • Chen, L.; Wang, Z.; Fang, E.; Guo, Y.; Liu, Z.; Song, W.; Li, H.; Xu, J.; Fan, Z.; Winnik, M. A.; Song, S. Recyclable Polypentenamers With Precise Crystallization And Versatile Functionalization. Macromolecules 2025, 58 (2), 1048–1059. DOI

2024

  • Jiang, J.; Nikbin, E.; Plaha, T. Singh; Howe, J. Y.; Winnik, M. A. Crystallization-Driven Self-Assembly Of Polyferrocenyldimethylsilane Block Copolymers With The Corona Modified With Pendant Amino Groups. Macromolecules 2024, 57, 3109–3120. DOI
  • Bardajee, G. Rezanejade; Mahmoodian, H.; Shafiei, N.; Ghadimkhani, R.; Winnik, M. A. Design, Synthesis, And Spectroscopic Profiling Of Novel Coumarin Dyes: Investigating Solvent Sensitivity And Photophysical Properties. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2024, 319. DOI
  • Liu, Y.; Wong, S. Hang; Halimi, I.; Fuku, R.; Hou, J.; Ragunathan, K.; Le Zhao, C. -; Soleimani, M.; Foley, N.; Walker, G. C.; Winnik, M. A. Film Formation And Molecular Mixing In Acrylic Latex Blends With An Acid-Rich Oligomer. Macromolecules 2024, 57 (16). DOI
  • Wong, E. C. N.; Zhang, Y.; Yang, T.; Liu, Y.; Abtahi, M.; Chen, X.; Ajayi, A. J.; Li, X.; Majonis, D.; Winnik, M. A. Optimizing The Structure Of A Pt Metal-Chelating Polymer To Reduce Nonspecific Binding For Mass Cytometry. Biomacromolecules 2024, 25 (10), 6716-6726. DOI
  • Li, X.; Liu, Y.; Zhang, Y.; Majonis, D.; Wang, M.; Fashandi, M.; Winnik, M. A. Preparation Of Functionalized Mesoporous Silica Nanoparticles As Mass Tags For Potential Applications In Mass Cytometry. Chemistry of Materials 2024, 36 (17), 8174-8187. DOI
  • Liu, Y.; Tran, K.; Ho, K.; Yang, T.; Li, X.; Wong, S. Hang; Zhang, M.; Walker, G.; Lucas, F.; Winnik, M. A. Stratification Of Polyisocyanate In Two-Component Waterborne Polyurethane Films. Chemical Engineering Journal 2024, 483. DOI
  • Abtahi, M.; Gheiratmand, L.; Dinesh, A.; Liu, Y.; Wong, E. C. N.; Cho, H.; Majonis, D.; Majonis, D.; Mrkonjic, M.; Winnik, M. A. Testing A Nanoparticle Reagent For Imaging Mass Cytometry. Biomacromolecules 2024, 25 (9). DOI
  • Huang, F.; Ma, J.; Nie, J.; Xu, B.; Huang, X.; Lu, G.; Winnik, M. A.; Feng, C. A Versatile Strategy Toward Donor–Acceptor Nanofibers With Tunable Length/composition And Enhanced Photocatalytic Activity. Journal of the American Chemical Society 2024, 146 (36). DOI
  • Tran, K.; Liu, Y.; Soleimani, M.; Lucas, F.; Winnik, M. A. Waterborne 2-Component Polyurethane Coatings Based On Acrylic Polyols With Secondary Alcohols. Progress in Organic Coatings 2024, 190. DOI

2023

  • Jiang, J.; Nikbin, E.; Liu, Y.; Lei, S.; Ye, G.; Howe, J. Y.; Manners, I.; Winnik, M. A. Defect-Induced Secondary Crystals Drive Two-Dimensional To Three-Dimensional Morphological Evolution In The Co-Self-Assembly Of Polyferrocenylsilane Block Copolymer And Homopolymer. Journal of the American Chemical Society 2023, 145, 28096–28110. DOI
  • Potter, N.; Latour, S.; Wong, E. C. N.; Winnik, M. A.; Jackson, H. W.; McGuigan, A. P.; Nitz, M. Design Parameters For A Mass Cytometry Detectable Halotag Ligand. Bioconjugate Chemistry 2023, 35, 80-91. DOI
  • Zhang, P.; Cheng, J.; Lu, Y.; Zhang, N.; Wu, X.; Lin, H.; Li, W.; Wang, J.; Winnik, M. A.; Gan, Z.; Hou, Y. Hypersensitive Mr Angiography Based On Interlocking Stratagem For Diagnosis Of Cardiac-Cerebral Vascular Diseases. Nature Communications 2023, 14, 6149. DOI
  • Jiang, J.; Nikbin, E.; Hicks, G.; Song, S.; Liu, Y.; Wong, E. C. N.; Manners, I.; Howe, J. Y.; Winnik, M. A. Polyferrocenylsilane Block Copolymer Spherulites In Dilute Solution. Journal of the American Chemical Society 2023, 145, 1247–1261. DOI
  • Arnett, L. P.; Rana, R.; Chung, W. Wai- Yip; Li, X.; Abtahi, M.; Majonis, D.; Bassan, J.; Nitz, M.; Winnik, M. A. Reagents For Mass Cytometry. Chemical Reviews 2023, 123, 1166–1205. DOI
  • Nie, J.; Huang, X.; Lu, G.; Winnik, M. A.; Feng, C. Synthesis And Living Crystallization-Driven Self-Assembly Of Backbone Asymmetric And Symmetric Π-Conjugated Oligo(P-Phenylene Ethynylene)-Based Block Copolymers. Polymer Chemistry 2023, 14, 137–151. DOI

2022

  • Cai, Z.; Liu, R.; Chan, C.; Lu, Y.; Winnik, M. A.; Cescon, D. W.; Reilly, R. M. 90Y-Labeled Gold Nanoparticle Depot (Npd) Combined With Anti-Pd-L1 Antibodies Strongly Inhibits The Growth Of 4T1 Tumors In Immunocompetent Mice And Induces An Abscopal Effect On A Distant Non-Irradiated Tumor. Molecular Pharmaceutics 2022, 19, 4199–4211. DOI
  • Arnett, L. P.; Liu, J.; Zhang, Y.; Cho, H.; Lu, E.; Closson, T.; Allo, B.; Winnik, M. A. Biotinylated Lipid-Coated Nalnf4 Nanoparticles (Lnnps): Demonstrating The Use Of Lnnp-Based Reporters In Mass Cytometry And Imaging Mass Cytometry. Langmuir 2022, 38, 2525–2537. DOI
  • Roberts, M. G.; Facca, V. J.; Keunen, R.; Yu, Q.; Reilly, R. M.; Winnik, M. A. Changing Surface Polyethylene Glycol Architecture Affects Elongated Nanoparticle Penetration Into Multicellular Tumor Spheroids. Biomacromolecules 2022, 23, 3296–3307. DOI
  • Liu, J.; Allo, B.; Winnik, M. A. Development Of Multiplexed Bead-Based Immunoassays For Profiling Soluble Cytokines And Cd163 Using Mass Cytometry. ACS Measurement Science Au 2022, 2, 629–640. DOI
  • Lu, E.; Pichaandi, J.; Rastogi, C. Kumar; Winnik, M. A. Effect Of Excess Ligand On The Reverse Microemulsion Silica Coating Of NaLnF4 Nanoparticles. Langmuir 2022, 38, 3316–3326. DOI
  • Yue, S.; Zhang, P.; Qin, M.; Zhu, L.; Qiao, Y.; Li, Q.; Lu, Y.; Wu, H.; Jiang, N.; Liu, C.; Winnik, M. A.; Hou, Y. An Enzyme-Like Activity Nanoprobe Based On Fe(Iii)–Rutin Hydrate Biomineral For Mr Imaging And Therapy Of Triple Negative Breast Cancer. Advanced Functional Materials 2022, 32. DOI
  • Liu, Y.; Tran, K.; Ho, K.; Emsermann, J.; Zhang, M.; Silva, P. P. de Oliv; Glenn, J.; Walker, G.; Lucas, F.; Soleimani, M.; Winnik, M. A. Influence Of Intraparticle Cross-Linking On Polymer Diffusion In Latex Films Prepared From Secondary Dispersions. Prog. Org. Coat. 2022, 164, 106691. DOI
  • Nie, J.; Huang, X.; Lu, G.; Winnik, M. A.; Feng, C. Living Crystallization-Driven Self-Assembly Of Linear And V-Shaped Oligo(P-Phenylene Ethynylene)-Containing Block Copolymers: Architecture Effect Of Π-Conjugated Crystalline Segment. Macromolecules 2022, 55, 7856–7868. DOI
  • Zhou, H.; Liu, Y.; Lu, Y.; Tran, K.; Glenn, J.; Zhang, M.; Soleimani, M.; Lucas, F.; Winnik, M. A. Monitoring The Reaction Kinetics Of Waterborne 2-Pack Polyurethane Coatings During Film Formation. Can. J. Chem. Eng. 2022, 100 (Kenneth O'Driscoll special issue), 703–713. DOI
  • Zhang, Y.; Liu, P.; Majonis, D.; Winnik, M. A. Polymeric Dipicolylamine-Based Mass Tags For Mass Cytometry. Chem. Sci. 2022, 13, 3233–3243. DOI
  • Song, S.; Jiang, J.; Manners, I.; Winnik, M. A. The Role Of Cooling Rate In Crystallization-Driven Block Copolymer Self-Assembly By Self-Seeding. Chemical Science 2022, 13, 396–409. DOI
  • Zhang, Y.; Rana, R.; Liu, P.; Zabinyakov, N.; Nitz, M.; Winnik, M. A. Tellurium-Containing Polymer For Mass Cytometry. European Polymer Journal 2022, 181, 111633. DOI
  • Georgiou, C. J.; Cai, Z.; Alsaden, N.; Cho, H.; Behboudi, M.; Winnik, M. A.; Rutka, J. T.; Reilly, R. M. Treatment Of Orthotopic U251 Human Glioblastoma Multiforme Tumors In Nrg Mice By Convection-Enhanced Delivery Of Gold Nanoparticles Labeled With The Β-Particle-Emitting Radionuclide, 177Lu. Molecular Pharmaceutics 2022, 20, 582–592. DOI

2021

  • Song, S.; Zhou, H.; Hicks, G.; Zhang, Y.; Jiang, J.; Manners, I.; Winnik, M. A. An Amphiphilic Corona-Forming Block Promotes Formation Of A Variety Of 2D Platelets Via Crystallization-Driven Block Copolymer Self-Assembly. Macromolecules 2021, 54, 9761–9772. DOI
  • Song, S.; Zhou, H.; Manners, I.; Winnik, M. A. Block Copolymer Self-Assembly: Polydisperse Corona-Forming Blocks Leading To Uniform Morphologies; Chem; 2021; Vol. 7, pp 2800–2821. DOI
  • Liu, J.; Wong, E.; Lu, E.; Jarzabek, J.; Majonis, D.; Winnik, M. A. Control Of Metal Content In Polystyrene Microbeads Prepared With Metal Complexes Of Dtpa Derivatives; Chem. Mater; 2021; Vol. 33, pp 3802–3813. DOI
  • Song, S.; Zhou, H.; Puzhitsky, M.; Zhang, Y.; Hicks, G.; Lu, Y.; Manners, I.; Winnik, M. A. Crystallization-Driven Self-Assembly Of A Block Copolymer With Amphiphilic Pendant Groups; Macromolecules; 2021; Vol. 54, pp 930–940. DOI
  • Liu, Y.; Glenn, J.; Tran, K.; Zhang, M.; Zhou, H.; Soleimani, M.; Lucas, F.; Winnik, M. A. Film Formation Of Waterborne 2K Polyurethanes: Effect Of Polyols Containing Different Carboxylic Acid Content; Macromolecules; 2021; Vol. 54, pp 7943–7954. DOI
  • Guérin, G.; Rupar, P. A.; Winnik, M. A. In-Depth Analysis Of The Effect Of Fragmentation On The Crystallization-Driven Self-Assembly Growth Kinetics Of 1D Micelles Studied By Seed Trapping. Polymers 2021, 13, 3122. DOI
  • Rastogi, C. K.; Lu, E.; Tam, J.; Pichaandi, J. M.; Howe, J.; Winnik, M. A. Influence Of The Sodium Precursor On The Cubic To Hexagonal Phase Transformation And Controlled Preparation Of Uniform Nandf4 Nanoparticles; Langmuir" volume = "37; 2021; pp 2146–2152. DOI
  • Lei, S.; Tian, J.; Fukui, T.; Winnik, M. A.; Manners, I. Probing The Analogy Between Living Crystallization-Driven Self-Assembly And Living Covalent Polymerizations: Length-Independent Growth Behavior For 1D Block Copolymer Nanofibers. Macromolecules 2021, 55, 359–369. DOI
  • Arnett, L.; Forbes, M. W.; Keunen, R.; Winnik, M. A. Scratching The Surface (Modification): Developing A Quantitative Lc-Ms/ms Method For The Investigation Of Pegylated And Non-Pegylated Lipid Mixtures On Lipid-Coated Lanthanide Nanoparticles; Langmuir; 2021; Vol. 37, pp 14605–14613. DOI
  • Wang, Z.; Ma, C.; Huang, X.; Lu, G.; Winnik, M. A.; Feng, C. Self-Seeding Of Oligo(P-Phenylenevinylene) -B-Poly(2-Vinylpyridine) Micelles: Effect Of Metal Ions; Macromolecules; 2021; Vol. 54, pp 6705–6717. DOI
  • Liu, J.; Jarzabek, J.; Roberts, M.; Majonis, D.; Winnik, M. A. A Silica Coating Approach To Enhance Bioconjugation On Metal-Encoded Polystyrene Microbeads For Bead-Based Assays In Mass Cytometry, Langmuir 2021, Xx, Xxx-Xxx; Langmuir; 2021; Vol. 37, pp 8240–8252. DOI
  • Le, P. J.; Miersch, S.; Forbes, M. W.; Jarvik, N.; Ku, A.; Sidhu, S. S.; Reilly, R. M.; Winnik, M. A. Site-Specific Conjugation Of Metal-Chelating Polymers To Anti-Frizzled 2 Antibodies Via Microbial Transglutaminase; Biomacromolecules; 2021; Vol. 22, pp 2491–2504. DOI
  • Song, S.; Zhou, H.; Ye, Y.; Tam, J.; Howe, J. Y.; Manners, I.; Winnik, M. A. Spherulite-Like Micelles. Angew. Chem. Int. Ed. 2021, 60, 10950–10956. DOI
  • Song, S.; Liu, X.; Nikbin, E.; Howe, J. Y.; Yu, Q.; Manners, I.; Winnik, M. A. Uniform 1D Micelles And Patchy And Block Comicelles Via Scalable, One-Step Crystallization-Driven Block Copolymer Self-Assembly. J. Am. Chem. Soc. 2021, 143, 6266–6280. DOI

2020

  • Zhou, H.; Liu, Y.; Zhang, M.; Lu, Y.; Arnett, L.; Soleimani, M.; Winnik, M. A. Characterization Of An Aqueous Dispersion Of A Hydrophilic Polyisocyanate For Waterborne 2-Pack Polyurethane Coatings. ACS Appl. Polym. Mater. 2020, 2, 1491–1499. DOI
  • Cho, H.; Al-sadan, N.; Lam, H.; Bus, J. M.; Reilly, R. M.; Winnik, M. A. *A Comparison Of Dfo And Dfo Conjugated To Trastuzumab-Dm1 For Complexing 89Zr - Micropet/ct Imaging In Nod/scid Mice With Her2-Positive Sk-Ov-3 Human Ovarian Cancer Xenografts. Nucl. Med. Biol. 2020*, 84-85*, 11-19. DOI
  • Tao, D.; Wang, Z.; Huang, X.; Lu, G.; Manners, I.; Winnik, M. A.; Feng, C. Continuous And Segmented Semiconducting Fiber-Like Nanostructures With Spatially Selective Functionalization By Living Crystallization-Driven Self-Assembly. 2020 2020, 59, 8232–8239. DOI
  • Song, S.; Puzhitsky, M.; Ye, S.; Abtahi, M.; Rastogi, C. R.; Lu, E.; Hicks, G.; Manners, I.; Winnik, M. A. Crystallization-Driven Self-Assembly Of Amphiphilic Triblock Terpolymers With Two Corona-Forming Blocks Of Distinct Hydrophilicities; Macromolecules; 2020; Vol. 53, pp 6576–6588. DOI
  • Yook, S.; Cai, Z.; Jeong, J. J.; Lu, Y.; Winnik, M. A.; Pignol, J. - P.; Reilly, R. M. A Dual Receptor-Targeted (Drt) Radiation Nanomedicine Labeled With 177Lu Is More Potent For Killing Human Breast Cancer Cells In Vitro That Co-Express Her2 And Egfr Than Single Receptor-Targeted (Srt) Radiation Nanomedicines. Mol. Pharmaceutics 2020, 17, 1226–1236. DOI
  • Grenier, L.; Beyler, M.; Closson, T.; Zabinyakov, N.; Bouzekri, A.; Zhang, Y.; Pichaandi, J. M.; Winnik, M. A.; Liu, P.; Ornatsky, O. I.; Baranov, V.; Tripier, R. Enabling Indium Channels For Mass Cytometry By Using Reinforced Cyclam-Based Chelating Polylysine. Bioconj. Chem. 2020, 31, 2103–2115. DOI
  • Roberts, M.; Yu, Q.; Keunen, R.; Liu, J.; Wong, E. D. N.; Rastogi, C.; Reilly, R. M.; Allen, C.; Winnik, M. A. Functionalization Of Cellulose Nanocrystals With A Mepoegma-Copolymer Via Copper Catalyzed Azide-Alkyne Cycloaddition For Potential Drug Delivery Applications. Biomacromolecules 2020, 21, 2014–2023. DOI
  • Cui, Y.; Wang, Z.; Huang, X.; Lu, G.; Manners, I.; Winnik, M. A.; Feng, C. How A Small Change Of Oligo(P-Phenylenevinylene) Chain Length Affects Self-Seeding Of Oligo(P-Phenylenevinylene) -Containing Block Copolymers. Macromolecules 2020, 53, 1831–1841. DOI
  • Yu, Q.; Roberts, M. G.; Houdaihed, L.; Liu, Y.; Ho, K.; Walker, G.; Allen, C. A.; Manners, I.; Reilly, R. M.; Winnik, M. A. Investigating The Influence Of Block Copolymer Length On Cellular Uptake And Penetration Into A Multicellular Tumor Spheroid Model. Nanoscale 2020, 13, 280–291. DOI
  • Tao, D.; Cui, Y.; Huang, X.; Lu, G.; Manners, I.; Winnik, M. A.; Feng, C. Mechanistic Study Of The Formation Of Fiber-Like Micelles With A -Conjugated Oligo(P-Phenylenevinylene) Core. J. Coll. Interfac. Sci. 2020, 560, 50–58. DOI
  • Liu, J.; Jarzabek, J.; Majonis, D.; Baranov, V.; Winnik, M. A. Metal-Encoded Polystyrene Microbeads As Mass Cytometry Calibration Standard Covering Channels From Yttrium (80) To Bismuth (209). Anal. Chem. 2020, 92, 999–1006. DOI
  • Liu, Y.; Zhou, H.; Tran, K.; Glenn, J.; Zhang, M.; Lu, Y.; Ho, K.; Soleimani, M.; Lucas, F.; Winnik, M. A. Monitoring Polymer Diffusion In A Waterborne 2K Polyurethane Formulation Based On An Acrylic Polyol Latex. Macromolecules 2020, 53, 20744–10753. DOI
  • Song, S.; Zhou, H.; Hicks, G.; Rastogi, C. R.; Yu, Q.; Manners, I.; Winnik, M. A. Single-Step Self-Assembly To Uniform Fiber-Like Core-Crystalline Block Copolymer Micelles. Chem. Comm. 2020, 56, 4595–4598. DOI
  • Song, S.; Yu, Q.; Zhou, H.; Hicks, G.; Zhu, H.; Rastogi, C. K.; Manners, I.; Winnik, M. A. Solvent Effects Leading To A Variety Of Different 2D Structures In The Self-Assembly Of A Crystalline-Coil Block Copolymer With An Amphiphilic Corona-Forming Block. Chemical Science 2020, 11, 4631–4643. DOI
  • Cho, H.; Liu, P.; Boyle, A.; Reilly, R. M.; Winnik, M. A. Synthesis Of Metal-Chelating Polymers For Chelating 64Cu Designed For Attachment To Antibodies. Eur. Polym. J. 2020, 125, 109501. DOI
  • Zhang, Y.; Zabinyakov, N.; Majonis, D.; Bouzekri, A.; Ornatsky, O.; Baranov, V.; Winnik, M. A. A Tantalum Oxide Nanoparticle-Based Mass Tag For Mass Cytometry. Anal. Chem. 2020, 92, 5741–5749. DOI
  • Guérin, G.; Molev, G.; Rupar, P.; Manners, I.; Winnik, M. A. Understanding The Dissolution And Regrowth Of Core-Crystalline Block Copolymer Micelles: A Scaling Approach; Macromolecules; 2020; Vol. 53, pp 10198–10211. DOI
  • Ma, C.; Wang, Z.; Huang, X.; Lu, G.; Manners, I.; Winnik, M. A.; Feng, C. Water-Dispersible, Colloidally Stable, Surface-Functionalizable Uniform Fiber-Like Micelle Containing A P-Conjugated Oligo(P-Phenylenevinylene)-Core Of Controlled Length. Macromolecules 2020, 53, 8009–8019. DOI

More publications from the group are available on Professor Mitch Winnik's Google Scholar page.